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Selective demethylation of quaternary salts with lithium propylmercaptide in hexamethylphosphoramide

✍ Scribed by Hutchins, Robert O.; Dux, Frank J.


Book ID
127305516
Publisher
American Chemical Society
Year
1973
Tongue
English
Weight
221 KB
Volume
38
Category
Article
ISSN
0022-3263

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6-O-Demethylation of the Thevinols with
✍ Simonβ€…W. Breeden; Andrew Coop; Stephenβ€…M. Husbands; Johnβ€…W. Lewis πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 German βš– 59 KB πŸ‘ 2 views

In the pursuit of ring-constrained analogues of buprenorphine, we wished to prepare 6-O-demethylated analogues of the thevinols and orvinols. Previously it had been disclosed that lithium aluminum hydride (LAH) in THF containing a chlorinated solvent could achieve this transformation. Here we report