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Selective Cyclooxygenase Inhibitors: Novel 1,2-Diarylcyclopentenes Are Potent and Orally Active COX-2 Inhibitors

โœ Scribed by Reitz, David B.; Li, James J.; Norton, Monica B.; Reinhard, Emily J.; Collins, Joe T.; Anderson, Gary D.; Gregory, Susan A.; Koboldt, Carol M.; Perkins, William E.


Book ID
126446934
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
417 KB
Volume
37
Category
Article
ISSN
0022-2623

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Novel 1,2-diarylcyclobutenes: Selective
โœ Richard W. Friesen; Daniel Dubรฉ; Rejean Fortin; Richard Frenette; Sylvie Prescot ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 347 KB

A series of novel 2,3-diaryl-2-cyclobuten-l-ones have been synthesized and have been evaluated with respect to their ability to inhibit the isozymes of cyclooxygenase, COX-1 and COX-2. 4,4-Dimethyl-2phenyl-3-[4-(methylsulfonyl)phenyl]cyclobutenone 22 was found to be highly selective for inhibition o