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Selective cyclooxygenase inhibitors: Novel 4-spiro 1,2-diarylcyclopentenes are potent and orally active cox-2 inhibitors

โœ Scribed by David B. Reitz; Horng-Chih Huang; James J. Li; Danny J. Garland; Robert E. Manning; Gary D. Anderson; Susan A. Gregory; Carol M. Koboldt; William E. Perkins; Karen Seibert; Peter C. Isakson


Book ID
108038826
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
305 KB
Volume
5
Category
Article
ISSN
0960-894X

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Novel 1,2-diarylcyclobutenes: Selective
โœ Richard W. Friesen; Daniel Dubรฉ; Rejean Fortin; Richard Frenette; Sylvie Prescot ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 347 KB

A series of novel 2,3-diaryl-2-cyclobuten-l-ones have been synthesized and have been evaluated with respect to their ability to inhibit the isozymes of cyclooxygenase, COX-1 and COX-2. 4,4-Dimethyl-2phenyl-3-[4-(methylsulfonyl)phenyl]cyclobutenone 22 was found to be highly selective for inhibition o