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Selective cyclooxygenase-2 inhibitors show a differential ability to inhibit proliferation and induce apoptosis of colon adenocarcinoma cells

✍ Scribed by Ryuta Yamazaki; Natsuko Kusunoki; Takeshi Matsuzaki; Shusuke Hashimoto; Shinichi Kawai


Book ID
117104807
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
321 KB
Volume
531
Category
Article
ISSN
0014-5793

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JTE-522, a selective cyclooxygenase-2 in
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## Abstract We have previously demonstrated that JTE‐522, a selective cyclooxygenase‐2 (COX‐2) inhibitor, inhibited development of aberrant crypt foci (ACF) in rats, a putative preneoplastic lesion in colon, and suggested its inhibitory potential in rat colon carcinogenesis. To evaluate the chemopr