Selective Cyclooxygenase-2 Inhibition: A Target in Cancer Prevention and Treatment
β Scribed by Suphat Subongkot; David Frame; William Leslie; Deborah Drajer
- Book ID
- 115048628
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 104 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0277-0008
No coin nor oath required. For personal study only.
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## Abstract Cyclooxygenaseβ2 (COXβ2), an enzyme that catalyzes the synthesis of prostaglandins, is overexpressed in a variety of premalignant and malignant conditions, including oral leukoplakia and squamous cell carcinoma of the head and neck. Increased levels of COXβ2 may contribute to carcinogen
## Abstract Cyclooxygenaseβ2 (COXβ2) is an inducible enzyme that regulates prostaglandin synthesis and is overexpressed at sites of inflammation and in several epithelial cancers. A causal link for COXβ2 in epithelial tumorigenesis was shown in genetically manipulated animal models of colon and bre