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Cyclooxygenase 2: a molecular target for cancer prevention and treatment

✍ Scribed by Kotha Subbaramaiah; Andrew J. Dannenberg


Book ID
117340999
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
513 KB
Volume
24
Category
Article
ISSN
0165-6147

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## Abstract Cyclooxygenase‐2 (COX‐2), an enzyme that catalyzes the synthesis of prostaglandins, is overexpressed in a variety of premalignant and malignant conditions, including oral leukoplakia and squamous cell carcinoma of the head and neck. Increased levels of COX‐2 may contribute to carcinogen

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## Abstract Cyclooxygenase‐2 (COX‐2) is an inducible enzyme that regulates prostaglandin synthesis and is overexpressed at sites of inflammation and in several epithelial cancers. A causal link for COX‐2 in epithelial tumorigenesis was shown in genetically manipulated animal models of colon and bre