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Selective cleavages of tRNAPhe with secondary and tertiary structures by enediyne antitumor antibiotics

✍ Scribed by Yukio Sugiura; Ryuichi Totsuka; Michihiro Araki; Yasushi Okuno


Book ID
108480580
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
832 KB
Volume
5
Category
Article
ISSN
0968-0896

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Sequence/structure selective thermal and
✍ Peter E. Nielsen; Niels Erik MΓΈllegaard πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 636 KB

The uranyl(V1) ion, UO:+, cleaves yeast tRNAPhe both thermally and photochemically. Photochemical cleavage takes place at all positions but exhibits maxima at , C49 and As\*. Furthermore, in the presence of stoichiometric concentrations of citrate, the cleavage is generally suppressed except that st