๐”– Bobbio Scriptorium
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Selective blockade of the discriminative stimulus effects of pentobarbital in pigeons

โœ Scribed by Seymore Herling; Gail Winger

Publisher
Springer
Year
1981
Tongue
English
Weight
287 KB
Volume
75
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

The ability of CNS stimulants to block the discriminative effects ofpentobarbital was studied in pigeons trained to discriminate IM pentobarbital (5 mg/kg) from saline. Pentobarbital, when administered alone, consistently produced greater than 90}' 0 pentobarbital-appropriate responding. The concomitant administration of pentobarbital and increasing doses of bemegride or pentylenetetrazol resulted in a dose-related decrease in pentobarbital-appropriate responses. In contrast, picrotoxin, another CNS stimulant, had little or no effect on pentobarbital-appropriate responding produced by pentobarbital.

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