## Analysis of camptothecins in biologic media is hampered by chemical hydrolysis of the parent lactone (form I) to an inactive hydroxy acid (form II). A solidphase extraction (SPE) method utilizing C2 -bonded silica particles (100 mg, 1 ml) is presented for simultaneous determination of forms I a
β¦ LIBER β¦
Selective and sensitive determination of lactone and hydroxy acid forms of camptothecin and two derivatives (CPT- 11 and SN-38) by high-performance liquid chromatography with fluorescence detection
β Scribed by Katsuya Akimoto; Akiko Goto; Kazumi Ohya
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 353 KB
- Volume
- 588
- Category
- Article
- ISSN
- 1873-3778
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