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Selective Alterations of Transcription Factors in MPP+-Induced Neurotoxicity in PC12 Cells

โœ Scribed by Z. Xu; D. Cawthon; K.A. McCastlain; H.M. Duhart; G.D. Newport; H. Fang; T.A. Patterson; W. Slikker Jr.; S.F. Ali

Book ID
116779555
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
348 KB
Volume
26
Category
Article
ISSN
0161-813X

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## Abstract In vivo, the neurotoxin MPTP is oxidated to MPP^+^, which is toxic to dopaminergic neurons. In this paper, we have used MPP^+^ as a tool to evoke neurotoxicity in the PC12 cell line and investigate the intracellular events that are involved. A cytotoxicity test, performed on undifferent