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D-β-Hydroxybutyrate Prevents MPP+-Induced Neurotoxicity in PC12 Cells

✍ Scribed by Baohua Cheng; Xinxin Yang; Chengchun Chen; Danfu Cheng; Xudong Xu; Xuewen Zhang

Book ID
106484308
Publisher
Springer
Year
2009
Tongue
English
Weight
368 KB
Volume
35
Category
Article
ISSN
0364-3190

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## Abstract In vivo, the neurotoxin MPTP is oxidated to MPP^+^, which is toxic to dopaminergic neurons. In this paper, we have used MPP^+^ as a tool to evoke neurotoxicity in the PC12 cell line and investigate the intracellular events that are involved. A cytotoxicity test, performed on undifferent