Selective 1H-NMR relaxation investigations of membrane-bound drugs in vitro: 1. Colchicine
β Scribed by Gianni Valensin; Andrea Lepri; Elena Gaggelli
- Book ID
- 103670785
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 399 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0301-4622
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π SIMILAR VOLUMES
The usefulness of 'H bi-selective relaxation times ( 2 ' : ' ) and selective relaxation times (T,') for structure and conformation determination is emphasized. A pulse sequence has been devised which provides the apparent observed T : ' . The cross-relaxations (q,) or Fi, values are derived from the
## Abstract ^1^H and ^13^C NMR parameters of methotrexate in [^2^H~6~]dimethyl sulphoxide were obtained and analysed in terms of a βpreferredβ conformation. The effective correlation time of the anisotropic motion of the pteridinylbenzoyl moiety was evaluated as __ca__. 10 ns at 300 K. The ^1^Hο£Ώ^1^
## Abstract The transverse nuclear ^1^H magnetization decay in poly(styreneβ__co__βbutadiene) (SBR) is investigated by editing ^13^C NMR spectra. This technique allows for the assignment of localized ^1^H dynamical information by discriminating the chemical sites based on their chemical shift in th