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1H and 13C NMR relaxation investigation of methotrexate in [2H6]dimethyl sulphoxide solution

✍ Scribed by Elena Gaggelli; Gianni Valensin; Antonio Vivi; Antonella Macotta

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 298 KB
Volume: 31
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.1260310502

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✦ Synopsis

Abstract

^1^H and ^13^C NMR parameters of methotrexate in [^2^H~6~]dimethyl sulphoxide were obtained and analysed in terms of a ‘preferred’ conformation. The effective correlation time of the anisotropic motion of the pteridinylbenzoyl moiety was evaluated as ca. 10 ns at 300 K. The ^1^H^1^H and ^13^C^1^H distances obtained were used to construct the molecular structure in solution.

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