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Selection in the expression of functionally distinct B-cell subsets

✍ Scribed by Norman R. Klinman


Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
651 KB
Volume
6
Category
Article
ISSN
0952-7915

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✦ Synopsis


Although the isolation and characterization of functionally distinct B-cel1 subsets has been a major preoccupation of immunologists for the past two decades, only recently has it been recognized that the various B-cel1 subsets may be disparately selected during their development and maturation on the basis of their expressed lg V regions. Thus, pre-6 cells are selected for clonal expansion and maturation by virtue of the amino-acid sequence of their nascent H chains and newly emerging B cells may be selected for longevity and subset distribution on the basis of both clonotype-specific and relatively non-specific interactions of their surface lg receptors.


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