Selecting Folded Proteins from a Library of Secondary Structural Elements
β Scribed by Graziano, James J.; Liu, Wenshe; Perera, Roshan; Geierstanger, Bernhard H.; Lesley, Scott A.; Schultz, Peter G.
- Book ID
- 127221631
- Publisher
- American Chemical Society
- Year
- 2008
- Tongue
- English
- Weight
- 505 KB
- Volume
- 130
- Category
- Article
- ISSN
- 0002-7863
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A simple method is presented for projecting the conformation of extended secondary structure elements of peptides and proteins that extend over four C a atoms onto a simple two-dimensional surface. A new set of two degrees of freedom is defined, a pseudodihedral involving four sequential C a atoms,
## Abstract This article describes a strategy to develop, starting from a __de novo__ design, bivalent peptides containing two different (Ξ±βhelix and Ξ²βhairpin) and independent secondaryβstructure elements. The design was based on the use of conformationally restricted peptide libraries. Structural