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Selected Combination Therapy with Sorafenib: A Review of Clinical Data and Perspectives in Advanced Solid Tumors

✍ Scribed by Dal Lago, L.; D'Hondt, V.; Awada, A.


Book ID
125420422
Publisher
Alphamed Press
Year
2008
Tongue
English
Weight
230 KB
Volume
13
Category
Article
ISSN
1083-7159

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi