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Seizure activity induces PIM-1 expression in brain

✍ Scribed by J.D. Feldman; L. Vician; M. Crispino; G. Tocco; M. Baudry; Harvey R. Herschman

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
138 KB
Volume
53
Category
Article
ISSN
0360-4012

No coin nor oath required. For personal study only.

✦ Synopsis

We recently identified KID-1, a previously undescribed protein kinase induced by depolarization in PC12 cells and brain (Feldman et al., 1998). KID-1 shares a high degree of sequence homology with PIM-1, a proto-oncogene previously reported to be expressed in hematopoietic and germ cells. We examined PIM-1 expression in stimulated PC12 cells, brains of kainic acid-treated rats, and a number of tissues from untreated rats. We now report that forskolin, but not depolarization or growth factors, induces PIM-1 expression in PC12 cells. PIM-1 is an immediate early gene induced in response to forskolin stimulation. We detect PIM-1 mRNA in a number of unstimulated tissues and at low levels in unstimulated brain. Systemic kainic acid administration to adult rats induces PIM-1 expression in the dentate gyrus region of the hippocampus.

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