Glutamate receptor GluR1 expression is altered selectively by chronic audiogenic seizures in the Frings mouse brain
✍ Scribed by Rogers, Scott W. ;Gahring, Lorise C. ;White, H. Steve
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 307 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0022-3034
No coin nor oath required. For personal study only.
✦ Synopsis
The audiogenic seizure-susceptible campus exhibited any qualitative changes in expresmouse, Frings, is genetically susceptible to sound-insion of these subunits. In 9 of the 21 Frings mice exhibduced seizures and provides a reliable model of reflex epilepsy that lasts throughout the life span of the aniiting increased GluR1, but in none of the controls, mal. We used immunohistochemistry to examine if the bilateral structural lesions were observed in the lateral expression of the non-N-methyl-D-aspartate glutahypothalamus. These results support a model where mate receptor (GluR) subunits GluR1, GluR2, or highly localized changes in the expression of GluR1 GluR3 were altered subsequent to multiple seizures.
occur in response to repeated audiogenic seizure. Following a regimen of one seizure per day for 3