Segregation of HLA-DR, -DQ and -DP phenotypes and restriction fragment length polymorphic fragments in two recombinant families
✍ Scribed by C. Munck Petersen; I. Juncker Søsrensen; J. J. Hyldig-Nielsen; L. U. Lamm
- Book ID
- 115093954
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 407 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0001-2815
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Key words: restriction fragment length polymorphism (RFLP), insulin gene 5' flanking polymorphism (5' FP), insulm gene 6.0-kb probe, Southern blotting, HLA-DBP band patterns, HLA-DQP band patterns, HLA-DR subtypes I NTROD UCTl ON A principal aim of the insulin-dependent diabetes mellitus (IDDM) comp
Linkage analysis of HLA DR antigen as well as DR and DQ restriction fragment length polymorphism (RFLP) data using the LIPED computer program and various three-allele disease locus models showed very close linkage to an insulindependent diabetes mellitus (1DDM)-susceptibility locus. RFLP data alone