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Segmental analysis of cardiac metabolism by hyperpolarized [1-13C] pyruvate: an in-vivo 3D MRI study in pigs

✍ Scribed by Vincenzo Positano; Maria Filomena Santarelli; Francesca Frijia; Giovanni Aquaro; Luca Menichetti; Vincenzo Lionetti; Giacomo Bianchi; Alessandra Flori; Jan Henrik Ardenkjaer-Larsen; Florian Wiesinger; Rolf F Schulte; Giulio Giovannetti; Fabio A Recchia; Luigi Landini; Massimo Lombardi

Publisher: BioMed Central
Year: 2012
Tongue: English
Weight: 717 KB
Volume: 14
Category: Article
ISSN: 1097-6647
DOI: 10.1186/1532-429x-14-s1-p56

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✦ Synopsis

An image analysis method was developed to obtain a 3D map of the pyruvate metabolites distribution in the LV in hyperpolarised 13C MRI. The obtained polar maps follow the standardized LV AHA segmentation, allowing reproducible and standardized LV segmental analysis.

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Metabolism of hyperpolarized [1-13C]pyru

Metabolism of hyperpolarized [1-13C]pyruvate in the isolated perfused rat lung – an ischemia study

✍ B. Pullinger; H. Profka; J. H. Ardenkjaer-Larsen; N. N. Kuzma; S. Kadlecek; R. R 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 204 KB

We report studies of the effect of ischemia on the metabolic activity of the intact perfused lung and its restoration after a period of reperfusion. Two groups of rat lungs were studied using hyperpolarized 1‐^13^C pyruvate to compare the rate of lactate labeling differing only in the temporal order