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Sedimentation coefficients of DNA topoisomers: The helical wormlike chain

✍ Scribed by Jiro Shimada; Hiromi Yamakawa

Publisher
Wiley (John Wiley & Sons)
Year
1988
Tongue
English
Weight
472 KB
Volume
27
Category
Article
ISSN
0006-3525

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✦ Synopsis

Synopsis

The sedimentation coefficient sN of the DNA topoisomer with the linking number N is evaluated as a function of N and chain length on the basis of a (circular) twisted wormlike chain, i.e., a special case of the helical wormlike chain. Evaluation is carried out by an application of the Oseen-Burgers procedure of hydrodynamics to the cylinder model with the preaveraged Oseen tensor. The necessary mean reciprocal distance between two contour points is obtained by a Monte Carlo method. It is shown that sN increases as IAN1 is increased from 0 in the range of small JANI,whereAN= N-W,with WthenumberofhelixtumsinthelinearDNAchainin the undeformed state. It is found that there is semiquantitative agreement between the Monte Carlo values and the experimental data obtained by Wang for sN.

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