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Securinine induces p73-dependent apoptosis preferentially in p53-deficient colon cancer cells

✍ Scribed by Rana, S.; Gupta, K.; Gomez, J.; Matsuyama, S.; Chakrabarti, A.; Agarwal, M. L.; Agarwal, A.; Agarwal, M. K.; Wald, D. N.

Book ID
120624381
Publisher
The Federation of American Societies for Experimental Biology
Year
2010
Tongue
English
Weight
383 KB
Volume
24
Category
Article
ISSN
0892-6638

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## Abstract __p53__‐related genes, __p73__ and __p63__, encode 2 classes of proteins, TA‐p73/p63 and Ξ”N‐p73/p63. TA‐p73/p63 demonstrate p53‐like properties including gene transactivation and cell death promotion, whereas Ξ”N‐p73/p63 lack these p53‐like functions. Although p53‐deficient cancer cells