## Abstract ## Objective To assess the quality of published randomized clinical trials (RCTs) in rheumatology and to determine whether there has been improvement in quality between 2 time periods, 1987โ1988 and 1997โ1998. ## Methods Using MEDLINE and a hand search of selected rheumatology journa
Secular Changes in Published Clinical Trials of Second-Line Agents in Rheumatoid Arthritis
โ Scribed by Jennifer J. Anderson; David T. Felson; Robert F. Meenan
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 587 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
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The randomized, controlled clinical trial has become the standard approach to evaluating the efficacy of slow-acting drugs in the treatment of rheumatoid arthritis (RA). Such trials, which were used as far back as the 1940s to evaluate antimalarial agents and gold and as recently as 1988 to evaluate