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Secretory transport of irinotecan metabolite SN-38 across isolated intestinal tissue

โœ Scribed by Shirou Itagaki; Yoshinobu Sumi; Soji Shimamoto; Tatsuya Itoh; Takeshi Hirano; Isao Takemoto; Ken Iseki


Publisher
Springer
Year
2005
Tongue
English
Weight
284 KB
Volume
55
Category
Article
ISSN
0344-5704

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pH-dependent uptake of irinotecan and it
โœ Kunihiko Kobayashi; Bernard Bouscarel; Yasushi Matsuzaki; Susan Ceryak; Shoji Ku ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 153 KB

Irinotecan (CPT-11) and its active metabolite, 7-ethyl-10hydroxycamptothecin (SN-38), are believed to be reabsorbed by intestinal cells and to enter the entero-hepatic circulation, but there is little information to date. Our objective was to investigate the intestinal transport of CPT-11 and SN-38