✦ LIBER ✦

Secretory component-dependent binding of immunoglobuin A in the rat, monkey and human: A comparison of intestine and liver

✍ Scribed by Christopher K. Daniels; Douglas L. Schmucker

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 505 KB
Volume: 7
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840070317

No coin nor oath required. For personal study only.

✦ Synopsis

The source and significance of immunoglobulin A in bile remains controversial. In the rat, and several other species, immunoglobulin A is transported through hepatocytes by a specific receptor, secretory component. In humans, immunohistochemical methods have indicated a distinct lack of receptors for immunoglobulin A on hepatocytes. Binding assays with 125I-immunoglobulin A and membranes from hepatocytes and intestinal cells of the rat display secretory component-dependent binding. Primate intestinal cells also show secretory component-specific binding of immunoglobulin A. Primate liver, on the other hand, does not show immunoglobulin A binding mediated by the polymeric immunoglobulin receptor.

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