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Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

✍ Scribed by Seubert, Peter; Oltersdorf, Tilman; Lee, Michael G.; Barbour, Robin; Blomquist, Cheryl; Davis, David L.; Bryant, Karin; Fritz, Lawrence C.; Galasko, Douglas; Thal, Leon J.


Book ID
109782995
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
505 KB
Volume
361
Category
Article
ISSN
0028-0836

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## Abstract The β‐amyloid protein (Aβ) is derived by proteolytic processing of the amyloid protein precursor (APP). Cleavage of APP by β‐secretase generates a C‐terminal fragment (APP‐CTFβ), which is subsequently cleaved by γ‐secretase to produce Aβ. Our previous studies have shown that the proteas