Secretion of Proteases fromPasteurella multocidaIsolates
β Scribed by Erasmo Negrete-Abascal; Victor R. Tenorio; Mireya de la Garza
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 713 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0343-8651
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Proteases were the principal secretory proteins of Clostridium sporogenes and were optimally produced after active growth at 37 Β° C. Glucose, ammonia and peptides repressed protease production. Protease formation was maximal in cultures grown at pH 6.5, but proteolytic activity exhibited a pH optimu
## Abstract Protease nexin (PN) is a cellβsecreted protein that links to thrombin (Th) and certain other serine proteases. PN mediates the binding, internalization, and degradation of these proteases by cells (Baker et al., 1980; Low et al., 1981). Here we show that binding of ThβPN complexes to hu
The pathogenic, Gram-negative bacteria, Neisseria gonorrhoeae, Neisseria meningitidis and Haemophilus injluenzae, secrete immunoglohulin A1 proteases into their extracellular surroundings. An extraordinary feature in the secretory pathway of these putative virulence factors is a self-directed outer