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The secretion pathway of IgA protease-type proteins in gram-negative bacteria

✍ Scribed by Thomas Klauser; Johannes Pohlner; Thomas F. Meyer


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
866 KB
Volume
15
Category
Article
ISSN
0265-9247

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✦ Synopsis


The pathogenic, Gram-negative bacteria, Neisseria gonorrhoeae, Neisseria meningitidis and Haemophilus injluenzae, secrete immunoglohulin A1 proteases into their extracellular surroundings. An extraordinary feature in the secretory pathway of these putative virulence factors is a self-directed outer membrane transport step allowing the proteins to he secreted autonomously, even from foreign Gram-negative host cells like Escherichia coli. Here we summarize recent achievements in the understanding of IgA protease outer memhrane translocation.


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