Surveillance colonoscopy and biopsy are inaccurate methods of predicting the likelihood of ulcerative colitis patients to develop colon carcinoma. We examined uPA and PAI-1 as potential markers for assessing these patients and those with familial polyposis who are at risk of developing colon cancer.
Secretion of active urokinase-type plasminogen activator from the yeastYarrowia lipolytica
β Scribed by Ho Myoung Ryu; Woo Kyu Kang; Hyun Ah Kang; Jeong-Yoon Kim
- Publisher
- The Korean Society for Biotechnology and Bioengineering
- Year
- 2003
- Tongue
- English
- Weight
- 134 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1226-8372
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Human blood rnonocytes in culture differentiate to macrophagelike cells within 1 week. Coinciding with this morphological transition the cells started releasing increasing amounts of the serine proteinase plasminogen activator (PA; Mr 56,000) of the urokinase (u-PA) type and the proteinase inhibitor
The urokinase-type plasminogen activator (u-PA) system consists of the serine proteinases plasmin and u-PA; the serpin inhibitors a 2 -anti-plasmin, PAI-1 and PAI-2; and the u-PA receptor (u-PAR). Two lines of evidence have strongly suggested an important and apparently causal role for the u-PA syst
The cDNA probe puPAR-2 detects two PstI polymorphisms in the urokinase-type plasminogen activator receptor gene (PLAUR). This probe and the polymorphic system are described.