Secondary Structure Peptide Mimetics: Design, Synthesis, and Evaluation of β-Strand Mimetic Thrombin Inhibitors
✍ Scribed by Boatman, P. Douglas; Ogbu, Cyprian O.; Eguchi, Masakatsu; Kim, Hwa-Ok; Nakanishi, Hiroshi; Cao, Bolong; Shea, J. Paul; Kahn, Michael
- Book ID
- 111895125
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 211 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-2623
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The synthesis of an 11 membered ring bis-lactam, a system which is designed as a conformationally restricted mimetic of type I and type II beta-turns is described. Computer assisted molecular modeling was used to compare the predicted low energy conformers of the turn mimetic with idealized type I a
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