Secondary structure of cell-penetrating peptides controls membrane interaction and insertion
✍ Scribed by Emelía Eiríksdóttir; Karidia Konate; Ülo Langel; Gilles Divita; Sébastien Deshayes
- Book ID
- 116274975
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 790 KB
- Volume
- 1798
- Category
- Article
- ISSN
- 0005-2736
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## Abstract Cell penetrating peptides (CPPs) have been successfully used to mediate the intracellular delivery of a wide variety of molecules of pharmacological interest both __in vitro__ and __in vivo__, although the mechanisms by which the cellular uptake occurs remain unclear and controversial.
## Abstract Interaction of the cell‐penetrating peptide (CPP) cysteine‐transportan (Cys‐TP) with model lipid membranes was examined by spin‐label electron paramagnetic resonance (EPR). Membranes were labeled with lipophilic spin probes and the influence of Cys‐TP on membrane structure was studied.