Secondary structure of a dynamic type I'beta-hairpin peptide
✍ Scribed by Stotz, C.E. ;Borchardt, R.T. ;Middaugh, C.R. ;Siahaan, T.J. ;Vander Velde, D. ;Topp, E.M.
- Book ID
- 110893757
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 638 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1397-002X
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📜 SIMILAR VOLUMES
Synthesis and conformational studies of two short peptides containing pyrrole amino acids (1, Paa), Boc-Paa-Paa-D-Pro-Gly-Xaa-Paa-Paa-OMe (2: Xaa=Ala; 3: Xaa=Val), were carried out in which it was established that replacement of Ala in 2 with a Val residue helps peptide 3 to adopt a well-defined b-h
## Abstract Designed octapeptides Boc‐Leu‐Val‐Val‐Aib‐^D^Xxx‐Leu‐Val‐Val‐OMe (^D^Xxx = ^D^Ala, 3a;^D^Val, 3c and ^D^Pro, 5a) and Boc‐Leu‐Phe‐Val‐Aib‐^D^Ala‐Leu‐Phe‐Val‐OMe (3b) have been investigated to construct models of a stable type I′ β‐turn nucleated hairpin and to generate systems for invest