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Nucleation of β-hairpin structure in a pyrrole amino acid containing peptide

✍ Scribed by Tushar K. Chakraborty; B.Krishna Mohan; S.Kiran Kumar; Ajit C. Kunwar

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
115 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

Synthesis and conformational studies of two short peptides containing pyrrole amino acids (1, Paa), Boc-Paa-Paa-D-Pro-Gly-Xaa-Paa-Paa-OMe (2: Xaa=Ala; 3: Xaa=Val), were carried out in which it was established that replacement of Ala in 2 with a Val residue helps peptide 3 to adopt a well-defined b-hairpin conformation in a nonpolar solvent, like CDCl 3 .

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