## Abstract Intramuscular injection of botulinum toxin type A is the treatment of choice for most cases of oromandibular dystonia. We report on five patients with oromandibular dystonia that developed secondary nonresponsiveness to botulinum toxin type A following multiple injections over a 6โyear
Secondary nonresponsiveness to new bulk botulinum toxin A (BCB2024)
โ Scribed by Brad A. Racette; Mikula Stambuk; Joel S. Perlmutter
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 394 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
โฆ Synopsis
Abstract
We report on a patient with cranioโcervical dystonia injected with the new, lower protein formulation of botulinum toxin A who developed secondary resistance to this toxin. Subsequent injections with botulinum toxin B provided substantial reduction of blepharospasm. This is the first reported case of secondary resistance to the new preparation of botulinum toxin A. ยฉ 2002 Movement Disorder Society
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## Abstract We studied 20 patients with cervical dystonia who had started to respond poorly to botulinum toxin A (BTXA) injections after an initial good response. All patients had extensor digitorum brevis (EDB) tests performed in addition to BTXA immunoprecipition assay (IPA) and mouse bioassay (M
Botulinum toxin (BTX) offers a new treatment option to reduce drooling in adults and children. Antibody formation against BTX is known to be one reason for clinical secondary nonโresponse to this treatment. This is a case report on the development of secondary nonโresponse to BTX type B (BTXโB) in a