𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Secondary Metabolites from the Stem Bark of Litsea akoensis and Their Cytotoxic Activity

✍ Scribed by Su-Yen Chang; Ming-Jen Cheng; Yueh-Hsiung Kuo; Shiow-Ju Lee; Hsun-Shuo Chang; Ih-Sheng Chen

Publisher
John Wiley and Sons
Year
2008
Tongue
German
Weight
213 KB
Volume
91
Category
Article
ISSN
0018-019X

No coin nor oath required. For personal study only.

✦ Synopsis

Six new butanolides, litseadioxanins A and B (1 and 2, resp.) bearing a 1,2-dioxane moiety, litseatrinolides A and B (3 and 4, resp.), and litseakolides D 1 and D 2 (5 and 6, resp.), were isolated from the stem bark of Litsea akoensis, together with six known compounds. The structures of the new compounds were characterized by in-depth NMR-spectroscopic and mass-spectrometric analyses. Butanolides 1 -4, and a mixture of 6 and litsenolide E 2 , and litsenolide B 1 were tested against human tumor cells, including MCF-7 (human breast adenocarcinoma), NCI-H460 (non-small-cell lung cancer), and SF-268 (glioblastoma) cell lines. Among the tested compounds, litsenolide B 1 exhibited marginal cytotoxic activity against MCF-7, NCI-H460, and SF-268 cell lines in vitro.

πŸ“œ SIMILAR VOLUMES

Secondary Metabolites from the Fungus Mo
Secondary Metabolites from the Fungus Monascus purpureus and Evaluation of Their Cytotoxic Activity
✍ Ming-Jen Cheng; Ping-Hsun Yang; Ming-Der Wu; Ih-Sheng Chen; Ming-Tsuen Hsieh; Ye πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 German βš– 330 KB

## Abstract Investigation of the 95% EtOH extract of red yeast rice fermented with the fungus __Monascus purpureus__ BCRC 31615 has led to the isolation and structure elucidation of four new compounds, including one new azaphilone analog, monascuspurpurone (**1**), a new isocoumarin, monaschromone

Secondary Metabolites from the Leaves of
Secondary Metabolites from the Leaves of Litsea lii var. nunkao-tahangensis
✍ Tzu-Ann Wang; Ming-Jen Cheng; Shiow-Ju Lee; Cheng-Wei Yang; Hsun-Shuo Chang; Ih- πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 German βš– 209 KB

## Abstract Investigation of the leaves extract of __Litsea lii__ var. __nunkao‐tahangensis__ led to the isolation of five new butanolides, litsealiicolide A (**1**), isolitsealiicolide A (**2**), litsealiicolide B (**3**), isolitsealiicolide B (**4**), and isolitsealiicolide C (**5**), along with