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Secondary Fungal Metabolites and Their Biological Activity, VIII. – Partial Synthesis of Oosponol, an Antifungal Isocoumarin

✍ Scribed by Kovács, Tibor ;Sonnenbichler, Johann

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
200 KB
Volume
1997
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

The partial synthesis of oosponol (4), which shows significant antibiotic activity, has been accomplished by enzyme catalyzed reactions including regioselective acetylation of (−)‐oospoglycol (1) followed by an oxidation step and hydrolysis by a lipase.

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ChemInform Abstract: Secondary Fungal Metabolites and Their Biological Activity. Part 8. Partial Synthesis of Oosponol, an Antifungal Isocoumarin.
✍ T. KOVACS; J. SONNENBICHLER 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB

Secondary Fungal Metabolites and Their Biological Activity. Part 8. Partial Synthesis of Oosponol, an Antifungal Isocoumarin. -The synthesis of title compound (V) is accomplished by enzyme catalyzed reactions including regioselective acetylation and hydrolysis by a lipase. -