## RESULTS. In specimens from 107 patients with NPC, EBV was detected by PCR in 2 Department of Pathology, the Johns Hopkins 97 cases (90.7%) and by EBER in situ hybridization in 105 cases (98.1%). In speci-
Second malignant tumors in patients with nasopharyngeal carcinoma and their association with Epstein-Barr virus
β Scribed by Chun-Chieh Wang; Mong-Liang Chen; Kuang-Hung Hsu; Steve P. Lee; Tse-Ching Chen; Yu-Sun Chang; Ngan-Ming Tsang; Ji-Hong Hong
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 51 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0020-7136
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The Epstein-Barr virus (EBV) open reading frame BHRF1, a homologue of the oncogene bcl-2, was cloned from a patient with nasopharyngeal carcinoma (NPC) and overexpressed in Escherichia coli. The resulting recombinant BHRF1 fusion protein, with an apparent molecular weight of 35 KD, was used as antig
Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) generally occurs in adults, especially in high-prevalence populations such as the Chinese and Eskimos. In Maghrebian populations, young patients affected with this malignancy represent 25% of the total NPC cases. In adults with NPC,