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Second-line mitoxantrone, etoposide, and cytarabine for acute myeloid leukemia: A single-center experience

โœ Scribed by Holbrook E. Kohrt; Samit Patel; Michelle Ho; Terri Owen; Daniel A. Pollyea; Ravindra Majeti; Jason Gotlib; Steve Coutre; Michaela Liedtke; Caroline Berube; Ash A. Alizadeh; Bruno C. Medeiros


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
117 KB
Volume
85
Category
Article
ISSN
0361-8609

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## Background: One potential mechanism of drug resistance to chemotherapy is the overexpression of multidrug resistance (mdr) genes coding for p-glycoprotein (p-gp), which leads to reduced intracellular retention of chemotherapy. this study tested the efficacy and toxicity of mitoxantrone, etoposid

Pharmacology of cytarabine given as a co
โœ Fevzi Ozkaynak, M.; Avramis, Vassilios I.; Carcich, Sherri; Ortega, Jorge A. ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 102 KB ๐Ÿ‘ 3 views

Background. The outcome of patients with acute myeloid leukemia (AML) who relapse or fail to achieve an initial remission has been dismal. Procedure. Fifteen pediatric patients with AML, 4 relapsed and 11 primary refractory, were reinduced with a loading bolus of 0.5 g/m 2 cytarabine (ara-C) followe