Second-line mitoxantrone, etoposide, and cytarabine for acute myeloid leukemia: A single-center experience
โ Scribed by Holbrook E. Kohrt; Samit Patel; Michelle Ho; Terri Owen; Daniel A. Pollyea; Ravindra Majeti; Jason Gotlib; Steve Coutre; Michaela Liedtke; Caroline Berube; Ash A. Alizadeh; Bruno C. Medeiros
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 117 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0361-8609
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## Background: One potential mechanism of drug resistance to chemotherapy is the overexpression of multidrug resistance (mdr) genes coding for p-glycoprotein (p-gp), which leads to reduced intracellular retention of chemotherapy. this study tested the efficacy and toxicity of mitoxantrone, etoposid
Background. The outcome of patients with acute myeloid leukemia (AML) who relapse or fail to achieve an initial remission has been dismal. Procedure. Fifteen pediatric patients with AML, 4 relapsed and 11 primary refractory, were reinduced with a loading bolus of 0.5 g/m 2 cytarabine (ara-C) followe