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“Second hit” of Tsc2 gene in radiation induced renal tumors of Eker rat model

✍ Scribed by Okio Hino; Hiroaki Mitani; Junko Sakaurai


Book ID
117550130
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
267 KB
Volume
1236
Category
Article
ISSN
0531-5131

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Molecular genetic basis of renal carcino
✍ Okio Hino; Etsuko Kobayashi; Youko Hirayama; Toshiyuki Kobayashi; Yoshiaki Kubo; 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 382 KB

## Abstract We have recently identified on rat chromosome 10q a germline mutation in the tuberous sclerosis gene(__Tsc2__), the gene predisposing to renal carcinoma(a) in the Eker rat. The homozygous mutant condition is lethal at around the 13th day of fetal life. In heterozygotes, RCs invariably d