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IntragenicTsc2Somatic Mutations as Knudson's Second Hit in Spontaneous and Chemically Induced Renal Carcinomas in the Eker Rat Model

โœ Scribed by Kobayashi, Toshiyuki ;Urakami, Shinji ;Hirayama, Youko ;Yamamoto, Toshiki ;Nishizawa, Masae ;Takahara, Tomoko ;Kubo, Yoshiaki ;Hino, Okio


Book ID
108581406
Publisher
Wiley (Blackwell Publishing)
Year
1997
Tongue
English
Weight
452 KB
Volume
88
Category
Article
ISSN
0910-5050

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Ki-ras mutations in spontaneous and chem
โœ Hiroko Ohgaki; Paul Kleihues; Gordon C. Hard ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 501 KB

A high frequency of point mutations at codon 12 of the Ki-ras gene has previously been reported for rat kidney mesenchymal tumors induced by methylating N-nitroso compounds. In this study, we analyzed renal tumors with divergent histogenesis, i.e., mesenchymal tumors (sarcomas), cortical epithelial