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Second-generation tyrosine kinase inhibitors reduce telomerase activity in K562 cells

✍ Scribed by Saar Shapira; Galit Granot; Rahav Mor-Tzuntz; Pia Raanani; Orit Uziel; Meir Lahav; Ofer Shpilberg


Book ID
116335909
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
867 KB
Volume
323
Category
Article
ISSN
0304-3835

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Second-generation tyrosine kinase inhibi
✍ Ayalew Tefferi πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 86 KB

Imatinib should continue to be the front‐line therapy for patients who have newly diagnosed chronic myelogenous leukemia accompanied by close monitoring. Patients should switch to a second‐generation tyrosine kinase inhibitor at the earliest sign of resistance or suboptimal response to imatinib.