✦ LIBER ✦

Searching high and low: Cancer stem cells in the eye

✍ Scribed by Konrad L. Streetz; Arndt Vogel

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 99 KB
Volume: 47
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.22368

No coin nor oath required. For personal study only.

✦ Synopsis

This study characterized cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) cell lines, tumor specimens, and blood samples. The CD90؉ cells, but not the CD90؊ cells, from HCC cell lines displayed tumorigenic capacity. All the tumor specimens and 91.6% of blood samples from liver cancer patients bore the CD45؊CD90؉ population, which could generate tumor nodules in immunodeficient mice. The CD90؉CD44؉ cells demonstrated a more aggressive phenotype than the CD90؉CD44؊ counterpart and formed metastatic lesions in the lung of immunodeficient mice. CD44 blockade prevented the formation of local and metastatic tumor nodules by the CD90؉ cells. Differential gene expression profiles were identified in the CD45؊CD90؉ and CD45؊CD90؊ cells isolated from tissue and blood samples from liver cancer patients and controls.

📜 SIMILAR VOLUMES

Searching for adult stem cells in the in

Searching for adult stem cells in the intestine

✍ Hans Clevers 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 282 KB 👁 1 views

Cancer initiating cells or cancer stem c

Cancer initiating cells or cancer stem cells in the gastrointestinal tract and liver

✍ Gang-Ming Zou 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 126 KB 👁 2 views

## Abstract It has been suggested that cancer stem cells population within the solid tumor with indefinite proliferation potential drives the growth and metastasis of cancer. In literature, these malignant stem cells also named Cancer initiating cells. Cancer stem cells exhibit low rate of division

The tissue banking in cancer and stem ce

The tissue banking in cancer and stem cell research

✍ Antonio Graziano; Ida Biunno; Pasquale De Blasio; Antonio Giordano 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 90 KB 👁 1 views

## Abstract The Sapio Award was established in 1999 by the Sapio Group along with several Italian universities and research centers to recognize Italian scientists who have made a major contribution to the discovery or development of novel technologies in the fields of biotechnology, social and hea

The stem cell hypothesis in head and nec

The stem cell hypothesis in head and neck cancer

✍ A. Graziano; R. d'Aquino; V. Tirino; V. Desiderio; A. Rossi; G. Pirozzi 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 67 KB 👁 1 views

## Abstract Cancer stem cells (CSCs) are tumoral cells which have stem features such as self‐renewal, high migration capacity, drug resistance, high proliferation abilities. In the last 10 years the pathological meaning and the existence of CSCs have been matter of discussion and a large number of

Cancer stem cells in gliomas: Identifyin

Cancer stem cells in gliomas: Identifying and understanding the apex cell in cancer's hierarchy

✍ Monica Venere; Howard A. Fine; Peter B. Dirks; Jeremy N. Rich 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 139 KB 👁 1 views

## Abstract Neuro‐oncology research has rediscovered a complexity of nervous system cancers through the incorporation of cellular heterogeneity into tumor models with cellular subsets displaying stem‐cell characteristics. Self‐renewing cancer stem cells (CSCs) can propagate tumors and yield nontumo

The role of stem and circulating cells i

The role of stem and circulating cells in cancer metastasis

✍ Ruby Ghadially 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 70 KB 👁 1 views

## Abstract While many solid tumors have been reported to contain stem cell‐like cells termed cancer stem cells, the case for a melanoma stem cell has been debated over the last few years. Herein, we summarize current knowledge of melanoma‐initiating cells and provide an update on recently gained k