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Searching for susceptibility alleles: Emphasis on bilateral breast cancer

✍ Scribed by Evgeny N. Imyanitov; Cees J. Cornelisse; Peter Devilee

Book ID
102270031
Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
60 KB
Volume
121
Category
Article
ISSN
0020-7136

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✦ Synopsis

Dear Sir,

A positive family history is one of the most firmly established risk factors for breast cancer (BC). Women with at least one firstdegree relative with BC have an 1.8-fold risk to develop this disease themselves. 1 Several genes have been found to cause BC susceptibility, most notably BRCA1 and BRCA2, but together, they do not explain more than about 25% of this excess risk. 2 Because linkage studies in BRCA-negative families have not yielded new highly penetrant susceptibility genes, 3 it has been suggested that most of the remainder of familial risk is polygenic in nature. 4 One model, strongly dominating current searches for BC-predisposing genes, implies that a large proportion of BC

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## Abstract Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a combined analysis of four genome‐wide linkage screens, which included a total of 149 multiple