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Scyllo-inositol in normal aging human brain: 1H magnetic resonance spectroscopy study at 4 Tesla

✍ Scribed by Lana G. Kaiser; Norbert Schuff; Nathan Cashdollar; Michael W. Weiner

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
118 KB
Volume
18
Category
Article
ISSN
0952-3480

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✦ Synopsis

The scyllo-inositol and myo-inositol concentrations of 24 normal human subjects were measured in vivo using 1H magnetic resonance spectroscopy at 4 T. Single-voxel short-echo (TE = 15 ms) metabolite spectra were collected from the white matter region of the corona radiata. Test-retest studies performed on 10 normal subjects demonstrated coefficient of variation for scyllo-inositol measurement of 37%, compared with 6% for N-acetyl aspartate. Comparisons between old and young subjects showed higher concentration of scyllo-inositol and myo-inositol in older subjects and a trend for a correlation between scyllo-inositol and myo-inositol levels across subjects.

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