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Screening for MEN1 tumor suppressor gene mutations in sporadic pituitary tumors

โœ Scribed by Evans, C.-O.; Brown, M. R.; Parks, J. S.; Oyesiku, Nelson M.


Book ID
125334666
Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
280 KB
Volume
23
Category
Article
ISSN
0391-4097

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The PTEN (MMAC1/TEP1) tumor suppressor gene was recently isolated and mapped to human chromosome band 10q23. Homozygous deletions and mutations of PTEN were observed in cell lines and sporadic cancers of the breast, kidney, and central nervous system. Germline mutations in PTEN were recently found i