Screening for hereditary non-polyposis colorectal cancer: A study of 22 kindreds in The Netherlands
β Scribed by Hans F.A. Vasen; Frieda C.A. den Hartog Jager; Fred H. Menko; Fokko M. Nagengast
- Book ID
- 115682726
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 513 KB
- Volume
- 86
- Category
- Article
- ISSN
- 1555-7162
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π SIMILAR VOLUMES
By means of PCR-SSCP and direct sequencing, we detected 12 germ-line mutations of hMSH2 or hMLH1 in 37 Japanese hereditary non-polyposis colorectal cancer (HNPCC) kindreds, of whom 15 satisfied the Amsterdam and 22 the Japanese criteria. The germ-line mutation detection rate of hMSH2 was much higher
Hereditary non-polyposis colorectal cancer (HNPCC) is known to be associated with several extracolonic cancers, e.g., cancers of the endometrium, stomach, urinary tract, small bowel and ovary. An association between HNPCC and brain tumours has also been reported, although previous risk analysis did