P386: Screening for endometrial cancer in a high-risk population (Hereditary Non Polyposis Colorectal Cancer)—a pilot study
✍ Scribed by E. Okaro; G. Condous; S. Goff; M. Alkatib; V. Murday; R. Eeles; S. Hodgson; T. Bourne
- Book ID
- 112230644
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 39 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0960-7692
- DOI
- 10.1002/uog.856
No coin nor oath required. For personal study only.
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## Abstract Hereditary non‐polyposis colorectal cancer (HNPCC) is an autosomal dominant disorder characterized by susceptibility to large‐bowel cancer, frequently with early onset and localized in the right colon. Several tumours of other sites may also occur with increased frequency in these famil
## Abstract Patients diagnosed with HNPCC harbouring a confirmed germline mutation in DNA mismatch repair (MMR) genes have an 80% lifetime risk of developing an epithelial malignancy. There is, however, considerable variation in the age of disease onset in these patients. Insulin‐like growth factor