Screening for Ha-ras oncogene mutations in human epidermal tumors by polymerase chain reaction
β Scribed by Liew, Foo Min; Yamanishi, K.; Konishi, K.; Kishimoto, S.; Yasuno, H.
- Book ID
- 122903787
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 129 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0923-1811
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Preliminary studies of RAS mutational activation in human testicular germ cell neoplasms have yielded conflicting results. Whereas two studies of clinical material revealed a significant incidence of Nand KRAS mutations, two studies of a variety of germ cell lines failed t o document RAS mutations.
We have studied 3 I male germ cell tumors (GCTs) for probable mutations in codons 12, 13, and 6 I of HRAS, KRAS, and NRAS oncogenes using the polymerase chain reaction. Twenty of the thirty-one tumors exhibited NRAS gene mutations, 14 in codon 6 I, and six in codon 12, whereas no mutations were dete