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Screening Alzheimer's disease patients for mutations in the amyloid precursor protein gene

✍ Scribed by C.T. Jones; S. Morris; A. Moffoot; D. St. Clair; D.J.H. Brock


Book ID
115637956
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
261 KB
Volume
7
Category
Article
ISSN
0890-8508

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We sequenced the entire coding region of the amyloid precursor protein (APP) genes of 11 unrelated patients with Japanese familial Alzheimer's disease (FAD) in order to determine the exact frequency of known APP gene mutations and to search for novel mutations responsible for FAD. Three out of 11 (2