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Scotopic stimulus/response relations of the B-wave of the electroretinogram

✍ Scribed by Anne B. Fulton; Ronald M. Hansen

Publisher: Springer-Verlag
Year: 1988
Tongue: English
Weight: 569 KB
Volume: 68
Category: Article
ISSN: 0012-4486
DOI: 10.1007/bf00156435

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✦ Synopsis

Scotopic b-wave stimulus/response (S/R) functions are abnormal in several human retinal degenerative disorders. However, the mechanisms by which diseases affect the S/R parameters are not yet fully known. Three experiments were done to simulate functional pathologies known to occur in retinal degenerations: 1) attenuated sensitivity of retinal units, 2) loss of rhodopsin, 3) loss of sensitivity with little or no loss of rhodopsin. None of the experimental perturbations of normal function replicated the pattern of S/R abnormalities caused by retinal degenerations. Thus, in the retinal degenerative disorders intrinsic abnormalities of cellular processing must affect the organization of distal retinal function indexed by the b-wave.

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